Article

Comparing Neuroprotective Drug Efficacy in Rodent Neonatal Brain Injury Models

2025-09-19

Abstract excerpt

<h4>Background</h4> A challenge in preclinical neonatal neuroprotection research is implementation of study designs that enable direct comparison of multiple potentially effective drugs. We used adaptive design to test four FDA approved drugs (azithromycin, erythropoietin, caffeine, melatonin) concurrently and determine which best combined safety and efficacy. <h4>Methods</h4> Seven-day-old (P7) rats underwent h...

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Literature Corpus work: cb7a767e-c8e1-599b-8a28-ef04b0bb4a57
DOI: 10.1101/2025.09.17.676833

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