TNFα polymorphism as marker of immunosenescence for rheumatoid arthritis patients.

doi:10.1016/j.exger.2014.12.009

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Article

TNFα polymorphism as marker of immunosenescence for rheumatoid arthritis patients.

Experimental gerontology - 1 Jan 2015

Rodríguez-Carrio Javier, Alperi-López Mercedes, López Patricia, Alonso-Castro Sara, Ballina-García Francisco J, Suárez Ana

Abstract excerpt

BACKGROUND: Expansion of CD4(+)CD28(null), a common feature of immunosenescence, which has been reported in rheumatoid arthritis (RA) patients, may also be associated with a CD4(+) imbalance. Although the increase of CD4(+)CD28(null) cells has been related to TNFα exposure, nothing is known about the possible role of genetic variants of this cytokine. METHODS: Participants were genotyped for TNFA rs1800629 (-308...

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PMID: 25510954
DOI: 10.1016/j.exger.2014.12.009

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