Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Importance of Hypervariable Region 2 for Stability and Affinity of a Shark Single-Domain Antibody Specific for Ebola Virus Nucleoprotein

5 Aug 2016

Abstract excerpt

Single-domain antibodies derived from the unique New Antigen Receptor found in sharks have numerous potential applications, ranging from diagnostic reagents to therapeutics. Shark-derived single-domain antibodies possess the same characteristic ability to refold after heat denaturation found in single-domain antibodies derived from camelid heavy-chain-only antibodies. Recently, two shark derived single-domain...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacteriophages and microbial interactions
Share to Monoclonal and Polyclonal Antibodies Research
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27494523
DOI: 10.1371/journal.pone.0160534

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Importance of Hypervariable Region 2 for Stability and Affinity of a Shark Single-Domain Antibody Specific for Ebola Virus NucleoproteinPMID 27494523Read ↗

Enhancing Stability of Camelid and Shark Single Domain Antibodies: An OverviewSemantic proximity Read ↗

Contributions of the complementarity determining regions to the thermal stability of a single-domain antibody.Semantic proximity Read ↗

Shark Variable New Antigen Receptor (VNAR) Single Domain Antibody Fragments: Stability and Diagnostic ApplicationsSemantic proximity Read ↗

Single antibody domains as small recognition units: design and in vitro antigen selection of camelized, human VH domains with improved protein stabilitySemantic proximity Read ↗

Evaluation of disulfide bond position to enhance the thermal stability of a highly stable single domain antibody.Semantic proximity Read ↗

Single domain antibody: Development and application in biotechnology and biopharmaSemantic proximity Read ↗

Improving solubility and refolding efficiency of human VHs by a novel mutational approachSemantic proximity Read ↗

Fully Human VH Single Domains That Rival the Stability and Cleft Recognition of Camelid AntibodiesSemantic proximity Read ↗

Functional Divergence in the Affinity and Stability of Non-Canonical Cysteines and Non-Canonical Disulfide Bonds: Insights from a VHH and VNAR Study.Semantic proximity Read ↗

Mechanisms of SARS-CoV-2 neutralization by shark variable new antigen receptors elucidated through X-ray crystallography.Semantic proximity Read ↗

Atypical Antigen Recognition Mode of a Shark Immunoglobulin New Antigen Receptor (IgNAR) Variable Domain Characterized by Humanization and Structural AnalysisSemantic proximity Read ↗

Isolation of a Highly Thermal Stable Lama Single Domain Antibody Specific for Staphylococcus aureusEnterotoxin BSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.