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Article

Statistical analysis of mutant allele frequency level of circulating cell-free DNA and blood cells in healthy individuals.

Scientific reports - 8 Aug 2017

Xia Ligang, Li Zhoufang, Zhou Bo, Tian Geng, Zeng Lidong, Dai Hongyu, Li Xiaohua, Liu Chaoyu, Lu Shixin, Xu Feiyue, Tu Xiaonian, Deng Fang, Xie Yuancai, Huang Weiren, He Jiankui

Abstract excerpt

Cell-free DNA (cfDNA) in plasma has emerged as a potential important biomarker in clinical diagnostics, particularly in cancer. However, somatic mutations are also commonly found in healthy individuals, which interfere with the effectiveness for cancer diagnostics. This study examined the background somatic mutations in white blood cells (WBC) and cfDNA in healthy controls based on sequencing data from 821...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28790338
DOI: 10.1038/s41598-017-06106-1
PMCID: PMC5548860

Genes

NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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