Article
A novel modulator domain of Ets transcription factors.
Genes & development - 1 Jun 1992
Wasylyk C, Kerckaert J P, Wasylyk B
Abstract excerpt
The ets gene family is composed of several oncogenes and codes for transcription factors. The Ets proteins have a similar sequence called the ets domain and bind to the core motif A/CGGAA. We show here that several members of the ets family have different trans-activating properties. The ets domain of Ets-1 is required for DNA binding. Adjacent to this domain there is a novel element that inhibits DNA binding. It...
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