Article
Two succeeding fibroblastic lineages drive dermal development and the transition from regeneration to scarring.
Nature cell biology - 1 Apr 2018
Jiang Dongsheng, Correa-Gallegos Donovan, Christ Simon, Stefanska Ania, Liu Juan, Ramesh Pushkar, Rajendran Vijayanand, De Santis Martina M, Wagner Darcy E, Rinkevich Yuval
Abstract excerpt
During fetal development, mammalian back-skin undergoes a natural transition in response to injury, from scarless regeneration to skin scarring. Here, we characterize dermal morphogenesis and follow two distinct embryonic fibroblast lineages, based on their history of expression of the engrailed 1 gene. We use single-cell fate-mapping, live three dimensional confocal imaging and in silico analysis coupled with...
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