Article
Effect of sequence variants on variance in glucose levels predicts type 2 diabetes risk and accounts for heritability.
Nature genetics - 1 Sept 2017
Ivarsdottir Erna V, Steinthorsdottir Valgerdur, Daneshpour Maryam S, Thorleifsson Gudmar, Sulem Patrick, Holm Hilma, Sigurdsson Snaevar, Hreidarsson Astradur B, Sigurdsson Gunnar, Bjarnason Ragnar, Thorsson Arni V, Benediktsson Rafn, Eyjolfsson Gudmundur, Sigurdardottir Olof, Olafsson Isleifur, Zeinali Sirous, Azizi Fereidoun, Thorsteinsdottir Unnur, Gudbjartsson Daniel F, Stefansson Kari
Abstract excerpt
Sequence variants that affect mean fasting glucose levels do not necessarily affect risk for type 2 diabetes (T2D). We assessed the effects of 36 reported glucose-associated sequence variants on between- and within-subject variance in fasting glucose levels in 69,142 Icelanders. The variant in TCF7L2 that increases fasting glucose levels increases between-subject variance (5.7% per allele, P = 4.2 × 10-10),...
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