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Article

Significance of microRNAs in Androgen Signaling and Prostate Cancer Progression

7 Aug 2017

Abstract excerpt

The androgen receptor (AR) plays important roles in prostate cancer development and prostate tumor growth. After binding to androgens, AR functions as a nuclear receptor and translocates to the nucleus to bind to specific AR-binding sites (ARBSs). AR regulates epigenetic factor recruitments to activate its downstream signaling. Although androgen deprivation therapy (ADT) is initially useful for prostate cancer...

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PMID: 28783103
DOI: 10.3390/cancers9080102

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