Article
Heritability in a SCN5A-mutation founder population with increased female susceptibility to non-nocturnal ventricular tachyarrhythmia and sudden cardiac death.
Heart rhythm - 1 Dec 2017
Ter Bekke Rachel M A, Isaacs Aaron, Barysenka Andrei, Hoos Marije B, Jongbloed Jan D H, Hoorntje Jan C A, Patelski Alfons S M, Helderman-van den Enden Apollonia T J M, van den Wijngaard Arthur, Stoll Monika, Volders Paul G A
Abstract excerpt
BACKGROUND: Heritable cardiac-sodium channel dysfunction is associated with various arrhythmia syndromes, some predisposing to ventricular fibrillation. Phenotypic diversity among carriers of identical-by-descent mutations is often remarkable, suggesting influences of genetic modifiers. OBJECTIVE: The purpose of this study was to identify a unique SCN5A-mutation founder population with mixed clinical phenotypes...
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