Article
Ventricular conduction is a marker for arrhythmic risk in SCN5A-E1784K overlap sodium channel disease.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology - 2 Jun 2026
Tanck Michael W T, Wijeyeratne Yanushi D, Barc Julien, Muir Alison, Aiba Takeshi, Bos J Martijn, Veltmann Christian, Galvin Joseph, Crotti Lia, Ishikawa Taisuke, Ohno Seiko, Page Stephen P, Denjoy Isabelle, Tester David J, Muggenthaler Martina, Takahashi Kazuhiro, Raju Hariharan, Gourraud Jean Baptiste, Redon Richard, Schott Jean-Jacques, Haglund-Turnquist Carla, Pedrazzini Matteo, Alberio Chiara, Dagradi Federica, Papadakis Michael, Sharma Sanjay, Petzer Edward, Roden Dan M, Horie Minoru, Schwartz Peter J, Makita Naomasa, Borggrefe Martin M, Ackerman Michael J, Shimizu Wataru, McKeown Pascal P, Probst Vincent, Behr Elijah R
Abstract excerpt
AIMS: SCN5A-E1784K (c.5350G>A) is the most common variant associated with the long QT (LQTS) and Brugada syndromes (BrS). It can manifest variably as LQTS, BrS, and/or conduction disorders. This presents a challenge for risk stratification. We aimed to describe clinical and ECG characteristics and identify risk markers that associate with arrhythmic events. METHODS AND RESULTS: We undertook a retrospective...
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