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Article

A Comparative Study of the Impact of Calcium Ion on Structure, Aggregation and Chaperone Function of Human αA-crystallin and its Cataract- Causing R12C Mutant.

Protein and peptide letters - 1 Jan 2017

Saba Sadaf, Ghahramani Maryam, Yousefi Reza

Abstract excerpt

BACKGROUND: The chaperone activity of α-crystallin (α-Cry) plays an important role in maintenance of eye lens transparency. Various mutations in the α-Cry genes have been indicated to cause cataract diseases in human. Also, the calcium imbalance has been shown to induce aggregation in α-Cry. We investigated the impact of calcium ion on structure, chaperone activity of the recombinant wild-type and mutant R12C...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28782478
DOI: 10.2174/0929866524666170807125658

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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