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Article

Conditional knock out of N-WASP in keratinocytes causes skin barrier defects and atopic dermatitis-like inflammation.

Scientific reports - 4 Aug 2017

Kalailingam Pazhanichamy, Tan Hui Bing, Jain Neeraj, Sng Ming Keat, Chan Jeremy Soon Kiat, Tan Nguan Soon, Thanabalu Thirumaran

Abstract excerpt

Neural-Wiskott Aldrich Syndrome Protein (N-WASP) is expressed ubiquitously and regulates actin cytoskeleton remodeling. In order to characterize the role of N-WASP in epidermal homeostasis and cutaneous biology, we generated conditional N-WASP knockout mouse using CK14-cre (cytokeratin 14) to ablate expression of N-WASP in keratinocytes. N-WASPK14KO (N-WASP fl/fl ; CK14-Cre) mice were born following Mendelian...

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Identifiers

PMID: 28779153
DOI: 10.1038/s41598-017-07125-8
PMCID: PMC5544743

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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