Article
Keratin 1 maintains skin integrity and participates in an inflammatory network in skin through interleukin-18.
Journal of cell science - 15 Nov 2012
Roth Wera, Kumar Vinod, Beer Hans-Dietmar, Richter Miriam, Wohlenberg Claudia, Reuter Ursula, Thiering Sören, Staratschek-Jox Andrea, Hofmann Andrea, Kreusch Fatima, Schultze Joachim L, Vogl Thomas, Roth Johannes, Reichelt Julia, Hausser Ingrid, Magin Thomas M
Abstract excerpt
Keratin 1 (KRT1) and its heterodimer partner keratin 10 (KRT10) are major constituents of the intermediate filament cytoskeleton in suprabasal epidermis. KRT1 mutations cause epidermolytic ichthyosis in humans, characterized by loss of barrier integrity and recurrent erythema. In search of the largely unknown pathomechanisms and the role of keratins in barrier formation and inflammation control, we show here that...
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