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Molecular profiling of pediatric meningiomas shows tumor characteristics distinct from adult meningiomas

8 Sept 2021

Abstract excerpt

In contrast to adults, meningiomas are uncommon tumors in childhood and adolescence. Whether adult and pediatric meningiomas differ on a molecular level is unclear. Here we report detailed genomic analyses of 37 pediatric meningiomas by sequencing and DNA methylation profiling. Histologically, the series was dominated by meningioma subtypes with aggressive behavior, with 70% of patients suffering from WHO grade...

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PMID: 34495383
DOI: 10.1007/s00401-021-02351-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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