Article
De Novo FGF12 (Fibroblast Growth Factor 12) Functional Variation Is Potentially Associated With Idiopathic Ventricular Tachycardia.
Journal of the American Heart Association - 3 Aug 2017
Li Qianqian, Zhao Yuanyuan, Wu Gang, Chen Shanshan, Zhou Yingchao, Li Sisi, Zhou Mengchen, Fan Qian, Pu Jielin, Hong Kui, Cheng Xiang, Kenneth Wang Qing, Tu Xin
Abstract excerpt
BACKGROUND: Idiopathic ventricular tachycardia (VT) is a type of cardiac arrhythmia occurring in structurally normal hearts. The heritability of idiopathic VT remains to be clarified, and numerous genetic factors responsible for development of idiopathic VT are as yet unclear. Variations in FGF12 (fibroblast growth factor 12), which is expressed in the human ventricle and modulates the cardiac Na+ channel NaV1.5,...
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