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Article

The S. pombe cytokinesis NDR kinase Sid2 activates Fin1 NIMA kinase to control mitotic commitment through Pom1/Wee1.

Nature cell biology - 10 Jun 2012

Grallert Agnes, Connolly Yvonne, Smith Duncan L, Simanis Viesturs, Hagan Iain M

Abstract excerpt

Mitotic exit integrates the reversal of the phosphorylation events initiated by mitotic kinases with a controlled cytokinesis event that cleaves the cell in two. The mitotic exit network (MEN) of budding yeast regulates both processes, whereas the fission yeast equivalent, the septum initiation network (SIN), controls only the execution of cytokinesis. The components and architecture of the SIN and MEN are highly...

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Identifiers

PMID: 22684255
DOI: 10.1038/ncb2514
PMCID: PMC4284365

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The S. pombe cytokinesis NDR kinase Sid2 activates Fin1 NIMA kinase to control mitotic commitment through Pom1/Wee1.PMID 22684255Read ↗

Saccharomyces cerevisiae Mob1p is required for cytokinesis and mitotic exit.Semantic proximity Read ↗

Recruitment of NIMA kinase shows that maturation of the S. pombe spindle-pole body occurs over consecutive cell cycles and reveals a role for NIMA in modulating SIN activity.Semantic proximity Read ↗

The SIN kinase Sid2 regulates cytoplasmic retention of the S. pombe Cdc14-like phosphatase Clp1.Semantic proximity Read ↗

IQGAP and mitotic exit network (MEN) proteins are required for cytokinesis and re-polarization of the actin cytoskeleton in the budding yeast, Saccharomyces cerevisiae.Semantic proximity Read ↗

Etd1p is a novel protein that links the SIN cascade with cytokinesis.Semantic proximity Read ↗

The nucleolar Net1/Cfi1-related protein Dnt1 antagonizes the septation initiation network in fission yeast.Semantic proximity Read ↗

Nuc2p, a subunit of the anaphase-promoting complex, inhibits septation initiation network following cytokinesis in fission yeast.Semantic proximity Read ↗

Dma1 prevents mitotic exit and cytokinesis by inhibiting the septation initiation network (SIN).Semantic proximity Read ↗

Dbf2-Mob1 drives relocalization of protein phosphatase Cdc14 to the cytoplasm during exit from mitosis.Semantic proximity Read ↗

Compartmentalized nodes control mitotic entry signaling in fission yeast.Semantic proximity Read ↗

Dialogue between centrosomal entrance and exit scaffold pathways regulates mitotic commitment.Semantic proximity Read ↗

The GIN4 family kinase, Cdr2p, acts independently of septins in fission yeast.Semantic proximity Read ↗

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