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The ω‐3 fatty acid α‐linolenic acid extends <i>Caenorhabditis elegans</i> lifespan via <scp>NHR</scp>‐49/<scp>PPAR</scp>α and oxidation to oxylipins

3 Aug 2017

Abstract excerpt

The dietary intake of ω-3 polyunsaturated fatty acids has been linked to a reduction in the incidence of aging-associated disease including cardiovascular disease and stroke. Additionally, long-lived Caenorhabditis elegans glp-1 germ line-less mutant animals show a number of changes in lipid metabolism including the increased production of the ω-3 fatty acid, α-linolenic acid (ALA). Here, we show that the...

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PMID: 28772063
DOI: 10.1111/acel.12651

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