Article
ACE Phenotyping as a Guide Toward Personalized Therapy With ACE Inhibitors.
Journal of cardiovascular pharmacology and therapeutics - 1 Jul 2017
Danilov Sergei M, Tovsky Stan I, Schwartz David E, Dull Randal O
Abstract excerpt
BACKGROUND: Angiotensin-converting enzyme (ACE) inhibitors (ACEI) are widely used in the management of cardiovascular diseases but with significant interindividual variability in the patient's response. OBJECTIVES: To investigate whether interindividual variability in the response to ACE inhibitors is explained by the "ACE phenotype"-for example, variability in plasma ACE concentration, activity, and conformation...
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