Article
Genetic Inhibition of Receptor Interacting Protein Kinase-1 Reduces Cell Death and Improves Functional Outcome After Intracerebral Hemorrhage in Mice.
Stroke - 1 Sept 2017
Lule Sevda, Wu Limin, McAllister Lauren M, Edmiston William J, Chung Joon Yong, Levy Emily, Zheng Yi, Gough Peter J, Bertin John, Degterev Alexei, Lo Eng H, Whalen Michael J
Abstract excerpt
BACKGROUND AND PURPOSE: Recent studies using cultured cells and rodent intracerebral hemorrhage (ICH) models have implicated RIPK1 (receptor interacting protein kinase-1) as a driver of programmed necrosis and secondary injury based on use of chemical inhibitors. However, these inhibitors have off-target effects and cannot be used alone to prove a role for RIPK1. The aim of the current study was to examine the...
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