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Article

Multiple cis-acting signals, some weak by necessity, collectively direct robust transport of oskar mRNA to the oocyte.

Journal of cell science - 15 Sept 2017

Ryu Young Hee, Kenny Andrew, Gim Youme, Snee Mark, Macdonald Paul M

Abstract excerpt

Localization of mRNAs can involve multiple steps, each with its own cis-acting localization signals and transport factors. How is the transition between different steps orchestrated? We show that the initial step in localization of Drosophila oskar mRNA - transport from nurse cells to the oocyte - relies on multiple cis-acting signals. Some of these are binding sites for the translational control factor Bruno,...

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Identifiers

PMID: 28760927
DOI: 10.1242/jcs.202069
PMCID: PMC5612174

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Multiple cis-acting signals, some weak by necessity, collectively direct robust transport of oskar mRNA to the oocyte.PMID 28760927Read ↗

Two distinct domains of Bruno bind specifically to the oskar mRNA.Semantic proximity Read ↗

Apontic binds the translational repressor Bruno and is implicated in regulation of oskar mRNA translation.Semantic proximity Read ↗

BREs mediate both repression and activation of oskar mRNA translation and act in trans.Semantic proximity Read ↗

Translational regulation of oskar mRNA by bruno, an ovarian RNA-binding protein, is essential.Semantic proximity Read ↗

A late phase of Oskar accumulation is crucial for posterior patterning of the Drosophila embryo, and is blocked by ectopic expression of Bruno.Semantic proximity Read ↗

Multiple RNA regulatory elements mediate distinct steps in localization of oskar mRNA.Semantic proximity Read ↗

Region-specific activation of oskar mRNA translation by inhibition of Bruno-mediated repression.Semantic proximity Read ↗

oskar RNA plays multiple noncoding roles to support oogenesis and maintain integrity of the germline/soma distinction.Semantic proximity Read ↗

Drosophila PTB promotes formation of high-order RNP particles and represses oskar translation.Semantic proximity Read ↗

Opposing roles for Egalitarian and Staufen in transport, anchoring and localization of oskar mRNA in the Drosophila oocyte.Semantic proximity Read ↗

Genetic interactions of Drosophila melanogaster arrest reveal roles for translational repressor Bruno in accumulation of Gurken and activity of Delta.Semantic proximity Read ↗

An architectural role of specific RNA-RNA interactions in oskar granules.Semantic proximity Read ↗

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