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Article

Region-specific activation of oskar mRNA translation by inhibition of Bruno-mediated repression.

PLoS genetics - 1 Jan 2015

Kim Goheun, Pai Chin-I, Sato Keiji, Person Maria D, Nakamura Akira, Macdonald Paul M

Abstract excerpt

A complex program of translational repression, mRNA localization, and translational activation ensures that Oskar (Osk) protein accumulates only at the posterior pole of the Drosophila oocyte. Inappropriate expression of Osk disrupts embryonic axial patterning, and is lethal. A key factor in translational repression is Bruno (Bru), which binds to regulatory elements in the osk mRNA 3' UTR. After posterior...

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Identifiers

PMID: 25723530
DOI: 10.1371/journal.pgen.1004992
PMCID: PMC4344327

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Region-specific activation of oskar mRNA translation by inhibition of Bruno-mediated repression.PMID 25723530Read ↗

Translational regulation of oskar mRNA by bruno, an ovarian RNA-binding protein, is essential.Semantic proximity Read ↗

Translational repressor bruno plays multiple roles in development and is widely conserved.Semantic proximity Read ↗

Two distinct domains of Bruno bind specifically to the oskar mRNA.Semantic proximity Read ↗

Apontic binds the translational repressor Bruno and is implicated in regulation of oskar mRNA translation.Semantic proximity Read ↗

A late phase of Oskar accumulation is crucial for posterior patterning of the Drosophila embryo, and is blocked by ectopic expression of Bruno.Semantic proximity Read ↗

Multiple cis-acting signals, some weak by necessity, collectively direct robust transport of oskar mRNA to the oocyte.Semantic proximity Read ↗

BREs mediate both repression and activation of oskar mRNA translation and act in trans.Semantic proximity Read ↗

oskar RNA plays multiple noncoding roles to support oogenesis and maintain integrity of the germline/soma distinction.Semantic proximity Read ↗

RNA sequences required for the noncoding function of oskar RNA also mediate regulation of Oskar protein expression by Bicoid Stability Factor.Semantic proximity Read ↗

Genetic interactions of Drosophila melanogaster arrest reveal roles for translational repressor Bruno in accumulation of Gurken and activity of Delta.Semantic proximity Read ↗

Drosophila cup is an eIF4E binding protein that associates with Bruno and regulates oskar mRNA translation in oogenesis.Semantic proximity Read ↗

Drosophila PTB promotes formation of high-order RNP particles and represses oskar translation.Semantic proximity Read ↗

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