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Mitofusin 1 and optic atrophy 1 shift metabolism to mitochondrial respiration during aging

31 Jul 2017

Abstract excerpt

Replicative and chronological lifespan are two different modes of cellular aging. Chronological lifespan is defined as the duration during which quiescent normal cells retain their capacity to re-enter the proliferative cycle. This study investigated whether changes in metabolism occur during aging of quiescent normal human fibroblasts (NHFs) and the mechanisms that regulate these changes. Bioenergetics...

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PMID: 28758339
DOI: 10.1111/acel.12649

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