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Article

A computational integrative approach based on alternative splicing analysis to compare immortalized and primary cancer cells.

The international journal of biochemistry & cell biology - 1 Oct 2017

Tripathi Kumar Parijat, Granata Ilaria, Guarracino Mario Rosario

Abstract excerpt

Immortalized cell lines are widely used to study the effectiveness and toxicity of anti cancer drugs as well as to assess the phenotypic characteristics of cancer cells, such as proliferation and migration ability. Unfortunately, cell lines often show extremely different properties than tumor tissues. Also the primary cells, that are deprived of the in vivo environment, might adapt to artificial conditions, and...

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PMID: 28757458
DOI: 10.1016/j.biocel.2017.07.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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