Article
Elevation of fumarase attenuates hypertension and can result from a nonsynonymous sequence variation or increased expression depending on rat strain.
Physiological genomics - 1 Sept 2017
Usa Kristie, Liu Yong, Geurts Aron M, Cheng Yuan, Lazar Jozef, Baker Maria Angeles, Grzybowski Michael, He Yongcheng, Tian Zhongmin, Liang Mingyu
Abstract excerpt
The activity of fumarase, an enzyme in the tricarboxylic acid cycle, is lower in Dahl salt-sensitive SS rats compared with SS.13BN rats. SS.13BN rats have a Brown Norway (BN) allele of fumarase and exhibit attenuated hypertension. The SS allele of fumarase differs from the BN allele by a K481E sequence variation. It remains unknown whether higher fumarase activities can attenuate hypertension and whether the...
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