Article
Increased expression of NAD(P)H oxidase subunit p67(phox) in the renal medulla contributes to excess oxidative stress and salt-sensitive hypertension.
Cell metabolism - 8 Feb 2012
Feng Di, Yang Chun, Geurts Aron M, Kurth Terry, Liang Mingyu, Lazar Jozef, Mattson David L, O'Connor Paul M, Cowley Allen W
Abstract excerpt
NAD(P)H oxidase has been shown to be important in the development of salt-sensitive hypertension. Here, we show that the expression of a subunit of NAD(P)H oxidase, p67(phox), was increased in response to a high-salt diet in the outer renal medulla of the Dahl salt-sensitive (SS) rat, an animal model for human salt-sensitive hypertension. The higher expression of p67(phox), not the other subunits observed, was...
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