Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Glutaric aciduria type 3 is a naturally occurring biochemical trait in inbred mice of 129 substrains.

Molecular genetics and metabolism - 1 Feb 2021

Leandro João, Bender Aaron, Dodatko Tetyana, Argmann Carmen, Yu Chunli, Houten Sander M

Abstract excerpt

The glutaric acidurias are a group of inborn errors of metabolism with different etiologies. Glutaric aciduria type 3 (GA3) is a biochemical phenotype with uncertain clinical relevance caused by a deficiency of succinyl-CoA:glutarate-CoA transferase (SUGCT). SUGCT catalyzes the succinyl-CoA-dependent conversion of glutaric acid into glutaryl-CoA preventing urinary loss of the organic acid. Here, we describe the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acyltransferases
Share to Amino Acid Metabolism, Inborn Errors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Glutarates

Share to Lysine

Share to Metabolic Diseases

Share to Mice, Inbred Strains

Share to Oxidoreductases

Share to Transferases

Source

Identifiers

PMID: 33483254
DOI: 10.1016/j.ymgme.2021.01.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Glutaric aciduria type 3 is a naturally occurring biochemical trait in inbred mice of 129 substrains.PMID 33483254Read ↗

Glutaric aciduria type 3 is a naturally occurring biochemical trait in inbred mice of 129 substrainsSemantic proximity Read ↗

Knockout of the non-essential gene SUGCT creates diet-linked, age-related microbiome disbalance with a diabetes-like metabolic syndrome phenotypeSemantic proximity Read ↗

Characterization, structure and inhibition of the human succinyl-CoA:glutarate-CoA transferase, a genetic modifier of glutaric aciduria type 1Semantic proximity Read ↗

Temporal metabolomics in dried bloodspots suggests multipathway disruptions in aldh5a1-/- mice, a model of succinic semialdehyde dehydrogenase deficiency.Semantic proximity Read ↗

Odd-chain dicarboxylic acid feeding recapitulates the biochemical phenotype of glutaric aciduria type 1 in miceSemantic proximity Read ↗

Genetic mapping of glutaric aciduria, type 3, to chromosome 7 and identification of mutations in c7orf10.Semantic proximity Read ↗

Therapeutic concepts in succinate semialdehyde dehydrogenase (SSADH; ALDH5a1) deficiency (gamma-hydroxybutyric aciduria). Hypotheses evolved from 25 years of patient evaluation, studies in Aldh5a1-/- mice and characterization of gamma-hydroxybutyric acid pharmacology.Semantic proximity Read ↗

Two patients with glutaric aciduria type 3: a novel mutation and brain magnetic resonance imaging findings.Semantic proximity Read ↗

Biochemical, pathologic and behavioral analysis of a mouse model of glutaric acidemia type I.Semantic proximity Read ↗

[Complex heterogeneity phenotypes and genotypes of glutaric aciduria type 1].Semantic proximity Read ↗

Understanding the Molecular Mechanisms of Succinic Semialdehyde Dehydrogenase Deficiency (SSADHD): Towards the Development of SSADH-Targeted MedicineSemantic proximity Read ↗

Glutaryl-CoA dehydrogenase deficiency in Spain: evidence of two groups of patients, genetically, and biochemically distinct.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.