Article
Analysis of metabolites in plasma reveals distinct metabolic features between Dahl salt-sensitive rats and consomic SS.13(BN) rats.
Biochemical and biophysical research communications - 18 Jul 2014
Wang Le, Hou Entai, Wang Zhengjun, Sun Na, He Liqing, Chen Lan, Liang Mingyu, Tian Zhongmin
Abstract excerpt
Salt-sensitive hypertension is a major risk factor for cardiovascular disorders. Our previous proteomic study revealed substantial differences in several proteins between Dahl salt-sensitive (SS) rats and salt-insensitive consomic SS.13(BN) rats. Subsequent experiments indicated a role of fumarase insufficiency in the development of hypertension in SS rats. In the present study, a global metabolic profiling study...
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