Article
Surfactant protein D inhibits activation of non-small cell lung cancer-associated mutant EGFR and affects clinical outcomes of patients.
Oncogene - 16 Nov 2017
Umeda Y, Hasegawa Y, Otsuka M, Ariki S, Takamiya R, Saito A, Uehara Y, Saijo H, Kuronuma K, Chiba H, Ohnishi H, Sakuma Y, Takahashi H, Kuroki Y, Takahashi M
Abstract excerpt
Tyrosine kinase inhibitor (TKI)-sensitive and TKI-resistant mutations of epidermal growth factor receptor (EGFR) are associated with lung adenocarcinoma. EGFR mutants were previously shown to exhibit ligand-independent activation. We have previously demonstrated that pulmonary surfactant protein D (SP-D, SFTPD) suppressed wild-type EGFR signaling by blocking ligand binding to EGFR. We herein demonstrate that...
Topics
- Animals
- CHO Cells
- Carcinoma, Non-Small-Cell Lung
- Cell Line, Tumor
- Cell Movement
- Cell Proliferation
- Cricetinae
- Cricetulus
- ErbB Receptors
- Humans
- Kaplan-Meier Estimate
- Lung Neoplasms
- Mutation