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Article

Epidermal growth factor signals regulate dihydropyrimidine dehydrogenase expression in EGFR-mutated non-small-cell lung cancer.

BMC cancer - 6 Jun 2016

Tominaga Tetsuro, Tsuchiya Tomoshi, Mochinaga Koji, Arai Junichi, Yamasaki Naoya, Matsumoto Keitaro, Miyazaki Takuro, Nagasaki Toshiya, Nanashima Atsushi, Tsukamoto Kazuhiro, Nagayasu Takeshi

Abstract excerpt

BACKGROUND: It has been shown that epidermal growth factor receptor (EGFR) mutation status is associated with 5-fluorouracil (5-FU) sensitivity in non-small-cell lung cancer (NSCLC). However, the relationship between EGFR mutation status and dihydropyrimidine dehydrogenase (DPD), a 5-FU degrading enzyme, is unknown. METHODS: We elucidated the crosstalk among the EGFR signal cascade, the DPD gene (DPYD), and DPD...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27268079
DOI: 10.1186/s12885-016-2392-0
PMCID: PMC4896005

Genes

EGFR
DPYD
EGF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Epidermal growth factor signals regulate dihydropyrimidine dehydrogenase expression in EGFR-mutated non-small-cell lung cancer.PMID 27268079Read ↗

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