Epidermal growth factor signals regulate dihydropyrimidine dehydrogenase expression in EGFR-mutated non-small-cell lung cancer.

doi:10.1186/s12885-016-2392-0

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Article

Epidermal growth factor signals regulate dihydropyrimidine dehydrogenase expression in EGFR-mutated non-small-cell lung cancer.

BMC cancer - 6 Jun 2016

Tominaga Tetsuro, Tsuchiya Tomoshi, Mochinaga Koji, Arai Junichi, Yamasaki Naoya, Matsumoto Keitaro, Miyazaki Takuro, Nagasaki Toshiya, Nanashima Atsushi, Tsukamoto Kazuhiro, Nagayasu Takeshi

Abstract excerpt

BACKGROUND: It has been shown that epidermal growth factor receptor (EGFR) mutation status is associated with 5-fluorouracil (5-FU) sensitivity in non-small-cell lung cancer (NSCLC). However, the relationship between EGFR mutation status and dihydropyrimidine dehydrogenase (DPD), a 5-FU degrading enzyme, is unknown. METHODS: We elucidated the crosstalk among the EGFR signal cascade, the DPD gene (DPYD), and DPD...

Topics

Carcinoma, Non-Small-Cell Lung
Cell Line, Tumor
Cell Survival
Dihydrouracil Dehydrogenase (NADP)
Drug Resistance, Neoplasm
Drug Synergism
Epidermal Growth Factor
ErbB Receptors
Fluorouracil

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gefitinib

Gene Expression Regulation, Neoplastic

Humans

Lung Neoplasms

Mutation

Plicamycin

Quinazolines

Signal Transduction

Sp1 Transcription Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 27268079
DOI: 10.1186/s12885-016-2392-0
PMCID: PMC4896005

Genes

EGFR
DPYD
EGF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-27268079-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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