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Article

Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B

15 Sept 2012

Abstract excerpt

Ribosomal protein (RP) mutations in diseases such as 5q- syndrome both disrupt hematopoiesis and increase the risk of developing hematologic malignancy. However, the mechanism by which RP mutations increase cancer risk has remained an important unanswered question. We show here that monoallelic, germline inactivation of the ribosomal protein L22 (Rpl22) predisposes T-lineage progenitors to transformation. Indeed,...

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PMID: 22976955
DOI: 10.1182/blood-2012-03-415349

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