Article
GNAS Spectrum of Disorders.
Current osteoporosis reports - 1 Jun 2015
Turan Serap, Bastepe Murat
Abstract excerpt
The GNAS complex locus encodes the alpha-subunit of the stimulatory G protein (Gsα), a ubiquitous signaling protein mediating the actions of many hormones, neurotransmitters, and paracrine/autocrine factors via generation of the second messenger cAMP. GNAS gives rise to other gene products, most of which exhibit exclusively monoallelic expression. In contrast, Gsα is expressed biallelically in most tissues;...
Topics
- Bone Diseases
- Chromogranins
- Exons
- Fibrous Dysplasia of Bone
- GTP-Binding Protein alpha Subunits, Gs
- Humans
- Mutation
- Pseudohypoparathyroidism