Article
Exploring the genetics and non-cell autonomous mechanisms underlying ALS/FTLD.
Cell death and differentiation - 1 Mar 2018
Chen Hongbo, Kankel Mark W, Su Susan C, Han Steve W S, Ofengeim Dimitry
Abstract excerpt
Although amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, was first described in 1874, a flurry of genetic discoveries in the last 10 years has markedly increased our understanding of this disease. These findings have not only enhanced our knowledge of mechanisms leading to ALS, but also have revealed that ALS shares many genetic causes with another neurodegenerative disease,...
Topics
- Amyotrophic Lateral Sclerosis
- Animals
- C9orf72 Protein
- Frontotemporal Dementia
- Humans
- Motor Neurons
- Mutation