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Article

Association between polymorphisms in CTR1, CTR2, ATP7A, and ATP7B and platinum resistance in epithelial ovarian cancer.

International journal of clinical pharmacology and therapeutics - 1 Oct 2017

Li Tailin, Peng Jingbo, Zeng Feiyue, Zhang Keqiang, Liu Jinyang, Li Xi, Ouyang Qianying, Wang Guo, Wang Liansheng, Liu Zhaoqian, Liu Yingzi

Abstract excerpt

The copper transporters <italic>CTR1</italic>, <italic>CTR2</italic>, <italic>ATP7A</italic>, and <italic>ATP7B</italic> regulate intracellular concentration of platinum by mediating its uptake and efflux in cells. We sought to explore the effect of genetic polymorphisms in <italic>CTR1</italic>, <italic>CTR2</italic>, <italic>ATP7A</italic>, and <italic>ATP7B</italic> on platinum resistance in patients suffering...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28737129
DOI: 10.5414/CP202907

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