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Article

ATP7B rs9535826 is associated with gastrointestinal toxicity of platinum-based chemotherapy in nonsmall cell lung cancer patients.

Journal of cancer research and therapeutics - 1 Jan 2018

Li Yue-Qin, Zhang Xin-Yin, Chen Juan, Yin Ji-Ye, Li Xiang-Ping

Abstract excerpt

AIMS: Platinum-based chemotherapy is considered as the first-line treatment for nonsmall cell lung cancer (NSCLC) patients. However, platinum resistance and toxicity are major obstacles to its clinical applications. The two P-type ATPases ATP7A and ATP7B have been identified to play an essential role in the transport of platinum. Their genetic polymorphisms may affect the treatment outcome and toxicity of...

Topics

Adult
Aged
Alleles
Antineoplastic Agents
Antineoplastic Combined Chemotherapy Protocols
Carcinoma, Non-Small-Cell Lung
Copper-Transporting ATPases
Female
Gastrointestinal Tract
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Kaplan-Meier Estimate

Lung Neoplasms

Male

Middle Aged

Neoplasm Staging

Pharmacogenomic Variants

Platinum

Source

Identifiers

PMID: 29970670
DOI: 10.4103/jcrt.JCRT_890_17

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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