Genetic polymorphisms of copper- and platinum drug-efflux transporters ATP7A and ATP7B in Japanese cancer patients.

doi:10.2133/dmpk.24.565

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Genetic polymorphisms of copper- and platinum drug-efflux transporters ATP7A and ATP7B in Japanese cancer patients.

Drug metabolism and pharmacokinetics - 1 Jan 2009

Fukushima-Uesaka Hiromi, Saito Yoshiro, Maekawa Keiko, Kurose Kouichi, Sugiyama Emiko, Katori Noriko, Kaniwa Nahoko, Hasegawa Ryuichi, Hamaguchi Tetsuya, Eguchi-Nakajima Takako, Kato Ken, Yamada Yasuhide, Shimada Yasuhiro, Yoshida Teruhiko, Yamamoto Noboru, Nokihara Hiroshi, Kunitoh Hideo, Ohe Yuichiro, Tamura Tomohide, Ura Takashi, Saito Miyuki, Muro Kei, Doi Toshihiko, Fuse Nozomu, Yoshino Takayuki, Ohtsu Atsushi, Saijo Nagahiro, Matsumura Yasuhiro, Okuda Haruhiro, Sawada Jun-ichi

Abstract excerpt

ATP7A and ATP7B are involved in cellular resistance to platinum compounds such as cisplatin. By sequencing ATP7A, 38 genetic variations, including 30 novel ones were detected from 203 Japanese cancer patients. Of these, seven nonsynonymous variations were found: novel 1030A>G (R344G), 2111A>G (Q7...

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PMID: 20045993
DOI: 10.2133/dmpk.24.565

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20045993-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

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