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Article

Polymorphisms in CYP3A5*3 and MDR1, and haplotype modulate response to plasma levels of tacrolimus in Chinese renal transplant patients.

Annals of transplantation - 1 Jan 2000

Wu Ping, Ni Xuefeng, Wang Mingli, Xu Xianlin, Luo Guanghua, Jiang Yan

Abstract excerpt

BACKGROUND: The purpose of this study was to investigate the effects of polymorphisms in CYP3A5*3, CYP3AP1, and MDR1, and of haplotype, on plasma levels of tacrolimus in Chinese patients after renal transplantation, and to assess the relationship between polymorphisms and the variability of concentration/dose of tacrolimus for optimization and individualization regimens. MATERIAL/METHODS: The MALDI-TOF method was...

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PMID: 21436775

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