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Article

Reciprocal Regulation of MicroRNA-122 and c-Myc in Hepatocellular Cancer: Role of E2F1 and Transcription Factor Dimerization Partner 2

28 Aug 2013

Abstract excerpt

UNLABELLED: c-Myc is a well-known oncogene frequently up-regulated in different malignancies, whereas liver-specific microRNA (miR)-122, a bona fide tumor suppressor, is down-regulated in hepatocellular cancer (HCC). Here we explored the underlying mechanism of reciprocal regulation of these two genes. Real-time reverse-transcription polymerase chain reaction (RT-PCR) and northern blot analysis demonstrated...

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PMID: 24038073
DOI: 10.1002/hep.26712

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