Article
Functions of idh1 and its mutation in the regulation of developmental hematopoiesis in zebrafish.
Blood - 7 May 2015
Shi Xiangguo, He Bai-Liang, Ma Alvin C H, Guo Yuhan, Chi Yali, Man Cheuk Him, Zhang Wenqing, Zhang Yiyue, Wen Zilong, Cheng Tao, Leung Anskar Y H
Abstract excerpt
Isocitrate dehydrogenase 1 mutation (IDH1-R132H) was recently identified in acute myeloid leukemia with normal cytogenetics. The mutant enzyme is thought to convert α-ketoglutarate to the pathogenic 2-hydroxyglutarate (2-HG) that affects DNA methylation via inhibition of ten-eleven translocation 2. However, the role of wild-type IDH1 in normal hematopoiesis and its relevance to acute myeloid leukemia is unknown....
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