Article

The Leukemic IDH1/2 Mutations Impair Myeloid and Erythroid Cell Differentiation of Primary Human Hematopoietic Stem and Progenitor Cells (HSPC): Experimental Evidences and a Review of the Literature

2024-06-25

Abstract excerpt

How hematopoietic stem and progenitor cell (HSPC) fate decisions are affected by genetic alterations acquired during AML leukemogenesis is poorly understood and mainly explored in animal models. Here, we studied isocitrate dehydrogenases (IDH) genes mutations in the human model of HSPC and provide a review of the literature on this topic. IDH1/2 mutations occur in ~20% of AML, are recognized among the mutations ea...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 887ee41b-c580-514f-9f20-390d852c5147
DOI: 10.20944/preprints202406.1723.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Leukemic IDH1/2 Mutations Impair Myeloid and Erythroid Cell Differentiation of Primary Human Hematopoietic Stem and Progenitor Cells (HSPC): Experimental Evidences and a Review of the LiteratureDOI 10.20944/preprints202406.1723.v1Read

Targeting IDH1 and IDH2 Mutations in Acute Myeloid Leukemia.Semantic proximity Read

IDH1/IDH2 Inhibition in Acute Myeloid LeukemiaSemantic proximity Read

Clinical Implications of Isocitrate Dehydrogenase Mutations and Targeted Treatment of Acute Myeloid Leukemia with Mutant Isocitrate Dehydrogenase Inhibitors-Recent Advances, Challenges and Future Prospects.Semantic proximity Read

IDH2 mutations in acute myeloid leukemia.Semantic proximity Read

Enasidenib for the treatment of acute myeloid leukemia.Semantic proximity Read

Targeting IDH Mutations in AML: Wielding the Double-edged Sword of Differentiation.Semantic proximity Read

The role of mutant IDH1 and IDH2 inhibitors in the treatment of acute myeloid leukemia.Semantic proximity Read

Combining Isocitrate Dehydrogenase Inhibitors With Existing Regimens in Acute Myeloid Leukemia: An Evolving Treatment Landscape.Semantic proximity Read

Isocitrate Dehydrogenase Inhibitors in Acute Myeloid Leukemia.Semantic proximity Read

Characteristics, clinical outcome, and prognostic significance of IDH mutations in AML.Semantic proximity Read

Isocitrate Dehydrogenase Mutations in Myelodysplastic Syndromes and in Acute Myeloid LeukemiasSemantic proximity Read

Enasidenib induces acute myeloid leukemia cell differentiation to promote clinical response.Semantic proximity Read