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Isocitrate dehydrogenase mutations in leukemia

2 Sept 2013

Abstract excerpt

Recent genome-wide discovery studies have identified a spectrum of mutations in different malignancies and have led to the elucidation of novel pathways that contribute to oncogenic transformation. The discovery of mutations in the genes encoding isocitrate dehydrogenase (IDH) has uncovered a critical role for altered metabolism in oncogenesis, and the neomorphic, oncogenic function of IDH mutations affects...

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PMID: 23999441
DOI: 10.1172/jci67266

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