miR‐181a mediates <scp>TGF</scp>‐β‐induced hepatocyte <scp>EMT</scp> and is dysregulated in cirrhosis and hepatocellular cancer

Abstract excerpt

BACKGROUND & AIMS: Epithelial-mesenchymal transition (EMT) has been implicated in the processes of embryogenesis, tissue fibrosis and carcinogenesis. Transforming growth factor-β (TGF-β) has been identified as a key driver of EMT and plays a key role in the pathogenesis of cirrhosis and hepatocellular carcinoma (HCC). The aim was to identify microRNA (miR) expression in TGF-β-induced hepatocyte EMT. METHODS: We...

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