Genetic diversity of the Mycobacterium tuberculosis Beijing family in Brazil and Mozambique and relation with infectivity and induction of necrosis in THP-1 cells.

doi:10.1016/j.tube.2015.02.025

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Genetic diversity of the Mycobacterium tuberculosis Beijing family in Brazil and Mozambique and relation with infectivity and induction of necrosis in THP-1 cells.

Tuberculosis (Edinburgh, Scotland) - 1 Jun 2015

Gomes Lia Lima, Vasconcellos Sidra Ezidrio Gonçalves, Gomes Harrison Magdinier, Elias Atina Ribeiro, da Silva Rocha Adalgiza, Ribeiro Simone C M, Panunto Alessandra Costa, Ferrazoli Lucilaine, da Silva Telles Maria Alice, Ivens de Araujo Marelo Emanuel, Kritski Afranio Lineu, Mokrousov Igor, Manicheva Olga A, Lasunskaia Elena, Suffys Philip Noel

Abstract excerpt

INTRODUCTION: The success of the Mycobacterium tuberculosis Beijing (MtbB) lineage in different geographical regions has been attributed to high transmission, increased virulence, drug resistance and rapid adaptation to the host. In some countries of secondary MtbB dispersion like South Africa and Peru, rising prevalence of the Beijing strains is registered. However, in neighboring countries to affected regions...

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PMID: 25841343
DOI: 10.1016/j.tube.2015.02.025

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