Functions of human liver CD69+CD103-CD8+ T cells depend on HIF-2α activity in healthy and pathologic livers.

doi:10.1016/j.jhep.2020.01.010

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Article

Functions of human liver CD69+CD103-CD8+ T cells depend on HIF-2α activity in healthy and pathologic livers.

Journal of hepatology - 1 Jun 2020

Kim Jong Hoon, Han Ji Won, Choi Young Joon, Rha Min-Seok, Koh June Young, Kim Kyung Hwan, Kim Chang Gon, Lee Yong Joon, Kim A Reum, Park Junsik, Kim Hong Kwan, Min Byung Soh, Seo Seong Il, Kang Minyong, Park Hye Jung, Han Dai Hoon, Kim Soon Il, Kim Myoung Soo, Lee Jae Geun, Lee Dong Hyeon, Kim Won, Park Jun Yong, Park Su-Hyung, Joo Dong Jin, Shin Eui-Cheol

Abstract excerpt

BACKGROUND & AIMS: Human liver CD69+CD8+ T cells are ~95% CD103- and ~5% CD103+. Although CD69+CD103+CD8+ T cells show tissue residency and robustly respond to antigens, CD69+CD103-CD8+ T cells are not yet well understood. METHODS: Liver perfusate and paired peripheral blood were collected from healthy living donors and recipients with cirrhosis during liver transplantation. Liver tissues were obtained from...

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PMID: 31987989
DOI: 10.1016/j.jhep.2020.01.010

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