Article
The molecular portraits of breast tumors are conserved across microarray platforms.
BMC genomics - 27 Apr 2006
Hu Zhiyuan, Fan Cheng, Oh Daniel S, Marron J S, He Xiaping, Qaqish Bahjat F, Livasy Chad, Carey Lisa A, Reynolds Evangeline, Dressler Lynn, Nobel Andrew, Parker Joel, Ewend Matthew G, Sawyer Lynda R, Wu Junyuan, Liu Yudong, Nanda Rita, Tretiakova Maria, Ruiz Orrico Alejandra, Dreher Donna, Palazzo Juan P, Perreard Laurent, Nelson Edward, Mone Mary, Hansen Heidi, Mullins Michael, Quackenbush John F, Ellis Matthew J, Olopade Olufunmilayo I, Bernard Philip S, Perou Charles M
Abstract excerpt
BACKGROUND: Validation of a novel gene expression signature in independent data sets is a critical step in the development of a clinically useful test for cancer patient risk-stratification. However, validation is often unconvincing because the size of the test set is typically small. To overcome this problem we used publicly available breast cancer gene expression data sets and a novel approach to data fusion,...
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