Article
An integrated computational-experimental approach reveals Yersinia pestis genes essential across a narrow or a broad range of environmental conditions.
BMC microbiology - 21 Jul 2017
Senior Nicola J, Sasidharan Kalesh, Saint Richard J, Scott Andrew E, Sarkar-Tyson Mitali, Ireland Philip M, Bullifent Helen L, Rong Yang Z, Moore Karen, Oyston Petra C F, Atkins Timothy P, Atkins Helen S, Soyer Orkun S, Titball Richard W
Abstract excerpt
BACKGROUND: The World Health Organization has categorized plague as a re-emerging disease and the potential for Yersinia pestis to also be used as a bioweapon makes the identification of new drug targets against this pathogen a priority. Environmental temperature is a key signal which regulates virulence of the bacterium. The bacterium normally grows outside the human host at 28 °C. Therefore, understanding the...
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