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Ephrin A1 functions as a ligand of EGFR to promote EMT and metastasis in gastric cancer

21 Jan 2025

Abstract excerpt

Distant metastasis is the major cause of gastric cancer mortality, and epidermal growth factor receptor (EGFR) activation plays critical roles in gastric cancer dissemination. However, EGFR targeting therapies in gastric cancer show only marginal effects, and the molecular mechanisms of oncogenic EGFR signaling remain poorly defined. Here, we report Ephrin A1 as a novel ligand of EGFR in gastric cancer. Ephrin A1...

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PMID: 39838173
DOI: 10.1038/s44318-025-00363-x

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