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A novel epidermal growth factor receptor-signaling platform and its targeted translation in pancreatic cancer

30 Aug 2013

Abstract excerpt

Epidermal growth factor (EGF)-induced EGFR tyrosine kinase receptor activation in cancer cell survival responses has become a strategic molecular-targeting clinical therapeutic intent, but the failures of these targeted approaches in the clinical setting demand alternate strategies. Here, we uncover a novel neuraminidase-1 (Neu1) and matrix metalloproteinase-9 (MMP-9) cross-talk in alliance with GPCR neuromedin...

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PMID: 23993964
DOI: 10.1016/j.cellsig.2013.08.008

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