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Article

Dysregulation of Serpinb6a-Gch1 axis contributes to DFNB91 deafness that is amendable to gene therapies.

Molecular therapy : the journal of the American Society of Gene Therapy - 6 May 2026

Cheng Cheng, Zhang Liyan, Lu Jie, Tan Fangzhi, Huang Yideng, Gao Song, Li Siyu, Qiu Yue, Hao Wenli, Zhou Yingyi, Lu Junze, Ji Xinya, Li Ao, Zhang Xinru, Fan Jinyi, Li He, Qian Xiaoyun, Qi Jieyu, Gao Xia, Chai Renjie

Abstract excerpt

Hereditary deafness accounts for 60% of congenital hearing loss, and more than 300 deafness genes have been identified. SERPINB6, a gene associated with recessive deafness, also named DFNB91, is linked to non-syndromic progressive hearing loss based on studies of humans and its mouse ortholog Serpinb6a knockout mice. However, the mechanism and biological therapy for SERPINB6 mutation-induced deafness remain...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41612696
DOI: 10.1016/j.ymthe.2026.01.030
PMCID: PMC13154291

Genes

SERPINB6
GCH1

Provenance

PubMed metadata and Literature Corpus relationships.

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