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Article

Deficiency of 5-hydroxyisourate hydrolase causes hepatomegaly and hepatocellular carcinoma in mice.

Proceedings of the National Academy of Sciences of the United States of America - 21 Sept 2010

Stevenson William S, Hyland Craig D, Zhang Jian-Guo, Morgan Phillip O, Willson Tracy A, Gill Anthony, Hilton Adrienne A, Viney Elizabeth M, Bahlo Melanie, Masters Seth L, Hennebry Sarah, Richardson Samantha J, Nicola Nicos A, Metcalf Donald, Hilton Douglas J, Roberts Andrew W, Alexander Warren S

Abstract excerpt

With the notable exception of humans, uric acid is degraded to (S)-allantoin in a biochemical pathway catalyzed by urate oxidase, 5-hydroxyisourate (HIU) hydrolase, and 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase in most vertebrate species. A point mutation in the gene encoding mouse HIU hydrolase, Urah, that perturbed uric acid metabolism within the liver was discovered during a mutagenesis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20823251
DOI: 10.1073/pnas.1010390107
PMCID: PMC2944704

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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