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Generation and analysis of spheroids from human primary skin myofibroblasts: an experimental system to study myofibroblasts deactivation

17 Jul 2017

Abstract excerpt

Abstract Myofibroblasts are activated fibroblasts involved in tissue repair and cancer. They are characterized byde novoexpression ofα-smooth muscle actin (α-SMA), immunoregulatory phenotype and paracrine interaction with normal and tumorigenic cells leading to cell proliferation. At the end of wound-healing myofibroblasts undergo apoptotic cell death, whereasin vitro-activated fibroblasts are also subjected to a...

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PMID: 28725488
DOI: 10.1038/cddiscovery.2017.38

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